Intrastricture steroid injections improve Esophageal Stricture Outcomes
Tarun Mullick, M.D., at the annual meeting of the American College of Gastroenterology, has suggested that intrastricture steroid injections should be used routinely as part of the treatment for complex esophageal strictures caused by acid-peptic disease that are smaller than 13 mm.
Intrastricture Kenalog injections significantly reduced the number of dilations needed to achieve a successful outcome by an average of about three, when compared with sham injections (4 vs. 7 dilations) in a randomized, placebo-controlled study of 120 patients.
From Internalmedicinenews.com:
The findings represent a major advancement in the treatment of complex esophageal strictures caused by acid-peptic disease, but steroid injections should be reserved only for those strictures smaller than 13 mm in size, he said.
In this study, 40 of 60 patients in the steroid group and 45 of 60 in the sham injection group had strictures smaller than 13 mm, and the therapeutic benefit of the steroid injections was entirely limited to these strictures.
Significantly fewer patients in the steroid group than in the sham injection group failed to achieve a successful outcome (0/60 vs. 9/60), which was defined as dilation of at least 18 mm. Failure to progress to the next size dilator occurred 2 times in the steroid group, compared with 132 times in the sham injection group; this difference was also statistically significant.
Dr. Mullick of Delnor-Community Hospital, Geneva, Ill. said intrastricture Kenalog injections improve quality of life as measured in terms of dysphagia, the ability to take pills, and effects on diet.


A non-surgical treatment with
Recent Comments