Posts Tagged ‘estrogen’

In wake of the recently released report by the American Medical Association’s (AMA) Council on Science and Public Health, Dr. Thomas T. Perls, an associate professor of medicine at Boston University School of Medicine condemned the promotion and distribution of growth hormones for non-medical purposes.

The criticism of growth hormones and appreciation of AMA for assessing risks and benefits of DHEA, growth hormone, testosterone, and estrogen was made by Dr. Perls editorial appearing in the Future Medicine journal Aging Health.

From Sciencedaily.com:

There have always been nostrums and potions peddled for eternal youth. Most recently these have been what some entrepreneurs call “bio-identical” or “all-natural” hormones. What they mean by these terms varies from substances made from vegetables — such as soy or yams, which some claim have estrogen-like effects to, more commonly, drugs that are exactly the same as hormones prescribed by endocrinologists for specific diseases. Dr. Perls remarked: “The terms bio-identical or all-natural, particularly in the case of the drugs prescribed by endocrinologists, misleadingly convey a sense of safety to the gullible customer. Arsenic is all-natural to, and it even has some medical uses, but it is anything but safe.”

“The AMA’s review of the risks and benefits of these hormones in the setting of anti-aging and athletic enhancement is very important given its inclusion of the consensus and position statements of the key professional medical societies as well as the federal agencies that guard public health.” states Dr. Perls in the editorial.

Dr. Perls denounced the marketing of hormones, especially growth hormone and anabolic steroids, for the purpose of anti-aging.

According to German researchers, concentrations of testosterone in men and estrogen in women (sex hormones) can have a positive effect on the regenerative potential of cartilage tissue.

Hormone replacement in the joint fluid of men and women could be useful for treating late stages of human osteoarthritis (OA) by regenerating damaged tissue, according to the study.

From Sciencedaily.com:

Nicolai Miosge, M.D., Ph.D., and colleagues from the August University in Goettingen, Germany examined the regenerative potential of chondrogenic progenitor cells (CPCs) that are present in arthritic tissue during the late stages of OA. The research team speculated that these CPCs might be influenced by sex steroids, and therefore hormone replacement therapy directed to the joint fluid could be beneficial in restoring damaged tissue. Tissue samples from 372 patients who underwent total knee replacement were analyzed. The mean age was 71 years of age for men and 72 years for women, with women representing 64.25% of participants.

Estrogens are known to influence bone metabolism and researchers found that 17β-estradiol (E2), which increases calcium deposition in both sexes, was present in the joint fluid of study participants. CPCs positive for estrogen receptors (ERα and ERβ) as well as androgen receptors were present in the OA tissue as well. Both estrogen and testosterone influenced the expression of all 3 receptor genes and the CPCs by regulating gene expression.

Details of this evidence-based study appeared in the April issue of Arthritis & Rheumatism, which is a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology.

If you have been searching for a powerful anabolic-androgenic steroid then Halotestin is what you are searching for. Read on!

Halotestin is a potent anabolic-androgenic steroid that is highly effective for developing muscle mass and muscle gains. This derivative of testosterone, the male sex hormone, does not come with any side effect unless abused or of a sub-standard quality.

In the world of bodybuilding and professional sports, Halotestin is generally used as a replacement for testosterone when there is some issue with the growth factor apart from being used as a performance enhancing drug.

In the world of medicines, Halotestin is also used as an anti-estrogen in women with breast carcinoma (cancer).

One of the biggest advantages with Halotestin is that it does not aromatize to estrogen, which means that the virilization and risk of androgenic side-effects is eliminated or reduced to a significant extent. The other significant advantage with Halotestin is that it is 19 times more anabolic and 8.5 times more androgenic than Testosterone, which is quite unbelievable to say the least. It also slows down the manifestation of estrogenic effects such as increased water retention that makes muscles more distinct and defined.

Recommended Dose

The recommended dose of Halotestin is 40 mg/day for a maximum period of 4-6 weeks at a stretch followed by a cooling period of 4-6 weeks.

Best place to buy Halotestin

The best place to buy Halotestin would be the Internet as you compare quality and price with different sellers.

In response to the recently released report by the American Medical Association’s (AMA) Council on Science and Public Health, a leading medical authority has criticized the use of anti-aging hormones.

Dr. Thomas T. Perls, an associate professor of medicine at Boston University School of Medicine has long been condemning the promotion and distribution of growth hormones for non-medical purposes such as sports and anti-aging.

From News-Medical.Net:

There have always been nostrums and potions peddled for eternal youth. Most recently these have been what some entrepreneurs call “bio-identical” or “all-natural” hormones. What they mean by these terms varies from substances made from vegetables – such as soy or yams, which some claim have estrogen-like effects to, more commonly, drugs that are exactly the same as hormones prescribed by endocrinologists for specific diseases. Dr. Perls remarked: “The terms bio-identical or all-natural, particularly in the case of the drugs prescribed by endocrinologists, misleadingly convey a sense of safety to the gullible customer. Arsenic is all-natural to, and it even has some medical uses, but it is anything but safe.”

“The AMA’s review of the risks and benefits of these hormones in the setting of anti-aging and athletic enhancement is very important given its inclusion of the consensus and position statements of the key professional medical societies as well as the federal agencies that guard public health.” states Dr. Perls in the editorial.

The editorial summarizes the AMA’s assessment for each of the purported anti-aging hormones and essentially the bottom line of his argument is that in terms of anti-aging, the risks of these hormones out-weigh the little or no benefit. Dr. Perls denounces the marketing of these hormones, particularly growth hormone and anabolic steroids (anabolic steroids are variations of testosterone), for anti-aging. He also provides guidelines for spotting “red flags of quackery” and basic advice that physicians can lend to their patients in their pursuit of healthy aging.

The example provided by the AMA in its recently published assessment of the benefits and risks of growth hormone, testosterone, estrogen, and DHEA for anti-aging was appreciated by Dr. Perls.

Concentrations of testosterone in men and estrogen in women, the sex hormone, could have a beneficial effect on regenerative potential of cartilage tissue according to researchers from Germany.

The study suggested that hormone replacement in the joint fluid of men and women may prove beneficial when it comes to treating late stages of human osteoarthritis (OA) via damaged tissue regeneration.

From Sciencedaily.com:

Nicolai Miosge, M.D., Ph.D., and colleagues from the August University in Goettingen, Germany examined the regenerative potential of chondrogenic progenitor cells (CPCs) that are present in arthritic tissue during the late stages of OA. The research team speculated that these CPCs might be influenced by sex steroids, and therefore hormone replacement therapy directed to the joint fluid could be beneficial in restoring damaged tissue. Tissue samples from 372 patients who underwent total knee replacement were analyzed. The mean age was 71 years of age for men and 72 years for women, with women representing 64.25% of participants.

Estrogens are known to influence bone metabolism and researchers found that 17β-estradiol (E2), which increases calcium deposition in both sexes, was present in the joint fluid of study participants. CPCs positive for estrogen receptors (ERα and ERβ) as well as androgen receptors were present in the OA tissue as well. Both estrogen and testosterone influenced the expression of all 3 receptor genes and the CPCs by regulating gene expression.

Details of this evidence-based study appeared in an issue of Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology.

There is a possible linkage between the increased risk for severe premenstrual depression and a certain genetic variation, as per scientists at the University of North Carolina at Chapel Hill and the National Institute of Mental Health.

The psychiatric condition, which is known as premenstrual dysphoric disorder or PMDD, tends to affect around eight percent of women in their child-bearing years and characterized by anxiety and severe irritability during second half of the menstrual cycle.

From News-Medical.Net:

Compared to the control group, women with PMDD were significantly more likely to have the ESR1 gene variants, the study found.

“While these are preliminary findings that require replication in larger studies, we would argue that this may explain part of the variance among women in the susceptibility to developing this mood disorder,” Rubinow said. “Studies have shown that PMDD is characterized by abnormal sensitivity to reproductive steroids like estrogen. As a receptor for the hormone that can trigger the onset of PMDD symptoms, ESR1 has clear physiologic relevance for this disorder.”

The authors acknowledge that as with other complex genetic disorders, the contribution to PMDD of polymorphisms in a single gene may not be large. In addition, they also noted that the findings may be telling us more about the control group.

Dr. David R. Rubinow, the study’s senior author and the Meymandi distinguished professor and chair of psychiatry at UNC School of Medicine, remarked that this study may provide insights as to why some women suffer mood changes and others do not and to examine the nature of this susceptibility.

Estrogen can halt stroke damage by inactivating a tumor-suppressing protein that is known to prevent many forms of cancer, as per researchers at the Medical College of Georgia.

It was remarked by Limor Raz, a fourth-year Ph.D. student in the MCG School of Graduate Studies, that estrogen has the potential of suppressing p53 after stroke leading to damage stoppage. It was also remarked that estrogen can also chemically alter p53 for attenuating the cascade and leading to reduced stroke damage.

From Sciencedaily.com:

Global cerebral ischemia, the most common type of ischemic stroke, in which blood flow to the brain is disrupted, was induced, damaging primarily the hippocampal CA1 region of the brain. In this study, a group of female rats were treated with estrogen versus placebo for seven days and estrogen’s effect on p53 signaling was examined.

“This part of the brain is extremely important because it is where our memory and learning occur,” Ms. Raz says. “During a stroke, you have all these things happening in your brain, and we’ve found that estrogen treatment is effective in reducing some of the damage.”

The next step, she says, is to determine why. “We know that it does, and now we need to find out how.”

Ms. Raz is presently working with Dr. Darrell Brann, chief of developmental neurobiology and associate director of the MCG Institute of Molecular Medicine and Genetics, and presented these research findings in Colorado at the American Physiological Society conference that focused on the cardiovascular effects of sex steroids and gender.

Letrozole or Femara is an effective medication when it comes to treating infertility for ovulation induction. The miracle drug, as it is termed by some doctors, is nowadays also used by bodybuilders and strength athletes to reduce or inhibit the formation of estrogens.

Letrozole has the unique ability to block estrogen to a significant extent. This means individuals using it run a significantly reduced risk of acne, gynecomastia, and water retention than individuals on other products. Moreover, it increases the levels of LH (Luteinizing hormone), FSH (Follicle-stimulating hormone), and SHBG (Sex hormone-binding globulin) to a significant extent. These are just a few reasons why all bodybuilders engaging themselves in bulking or cutting cycles prefer it.

It is also used in the world of medications for reversing the severity of breast cancer after Tamoxifen therapy is found or rendered ineffective.

The inactive ingredients of Letrozole tablets are sodium starch glycolate, talc, colloidal silicon dioxide, ferric oxide, hydroxypropyl methylcellulose, magnesium stearate, maize starch, microcrystalline cellulose, polyethylene glycol, lactose monohydrate, and titanium dioxide.

Tablets of Letrozole need to be kept at a controlled room temperature of 25°C (77°F) with excursions permitted up to 15-30°C (59-86°F). They need to be kept away from unauthorized usage, pets, children, heat, moisture, and sunlight.

Potential users intending to make use of Letrozole-Femara must initiate use only after a qualified medical advice to rule out the possibility of existing allergies and stay closer to benefits without coming in close proximity to side effects.