Trackdown of behind Chronic Rhinosinusitis with Polyps
A protein acknowledged for stimulating growth of blood vessels was recently found as the reason behind overgrowth of cells in polyps’ development characterizing one of the most severe forms of sinusitis.
This finding was disclosed during a study by researchers from Johns Hopkins that was aimed at offering a new target for development of new therapies to treat disease form, which typically resists all current treatments.
From Sciencedaily.com:
Kim explains that surgery to remove the polyps is one of the most common treatments for this disease. However, nasal and sinus polyps in these patients almost always regrow. “Once the patient has entered the cycle of growing polyps, it’s very hard to get out,” she says. Another common treatment is oral steroids, but these drugs are fraught with many harmful side effects and also only temporarily treat the disease.
She and her Johns Hopkins colleagues have long studied sinusitis, often growing sinus cells isolated from patients in petri dishes. After noticing that cells from patients with polyps typically multiplied faster than cells from normal patients, the researchers speculated that cells from polyp patients might be producing extra amounts of some type of growth factor, a protein that encourages cell growth.
Jean Kim, M.D., Ph.D., assistant professor in the Departments of Otolaryngology and Allergy and Clinical Immunology at the Johns Hopkins University School of Medicine, and a researcher at the Johns Hopkins Allergy and Asthma Center at the Johns Hopkins Bayview Medical Center, was of the view that this type of sinusitis is not subtle in nature.
Tags: oral steroids, sinusitis, Steroids
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