Steroid hormone stimulates activity of genes
Scientists at the University of Bristol and the National Cancer Institute (NCI), USA have suggested that intermittent signaling by steroid hormones can affect the manner by which genes are expressed in rodents.
The finding is considered to offer considerable implications for understanding how steroids operate and open up novel avenues for new therapies.
From News-Medical.Net:
In this new study, the researchers demonstrate that ultradian hormone stimulation induces the pulsed expression of genes (known as gene pulsing) over the same period, both in cultured cells and in animal models. Initially, the researchers administered corticosterone, a naturally occurring glucocorticoid hormone in rodents, in a pulsed manner to cultured mouse cells and then observed that the levels of newly synthesized RNA from glucocorticoid receptor-regulated genes tracked precisely with the hormone pulses.
The reported research results argue that gene pulsing regulated by glucocorticoid receptors is directly linked to varying levels of gene activity. Professor Stafford Lightman, head of the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, at the University of Bristol, said: “We have previously shown that the hormone cortisol is released in pulses in man as well as rodents. The present results now show that this pattern of hormone release is critical for good health and provides a novel concept for new drug design.”
The findings were published online and appeared in the September 2009 issue of Nature Cell Biology.
Tags: cortisol, steroid, steroid hormones, Steroids
hello…
really good article. Ready to hear more next week,my blog http://debbieqqq.onsugar.com/Adressing-Wedding-invites-Envelopes-17840597 Many Thanks….
hello…
really good article. Ready to hear more next week,my blog http://eveningdressesypqypq.wordpress.com/2011/06/12/adressing-wedding-invitations-envelopes/ Many Thanks….
really good article…
I have spent a bit of time going through your posts, more than I should have but I must say, its worth it! http://sherlly.newmalay.com/2011/03/26/short-prom-dresses/ many Thanks….
hello…
Hello there thanks for the quality post! http://monica11.beeplog.com/ ,i’d a good read.appreciate your article,My problem continues to be resolved….
very helpful…
I preferred to thank you for this good article. http://wqgmh.blogviaje.com/ I by all odds liked every little bit of it…
Great…
You did a great job! http://denna.sier.no/2011/06/20/ana-diaz-adverse-end-of-the-spectrum/...
quality post…
I have spent a bit of time going through your posts! http://delaine.blog.mugensite.net/2011/06/17/swimming-in-glamour/ ,i had a good read….
really…
Fat women and girls always worried because of their ugly shaped bodies. They want to wear expensive and stylish outfits . http://gftrxsaz.zeclic.fr/2011/06/17/a-line-wedding-dress-to-glam-up/ but they can not wear these outwears…
really…
Fat women and girls always worried because of their ugly shaped bodies. They want to wear expensive and stylish outfits . http://qilyhft.unblog.fr/ but they can not wear these outwears…
Great…
love your blog,take her for a drive where the prostitutes hang out and let her see what she loks like and tell her a good story, hopefully it will sink in tell her how women that dress like like get no respect, are often hookers, and do drugs and does …
Great…
love your blog,51280, http://blog.oricon.co.jp/rodney071/ ,Thanks again….