Genetic link recognized between immune system and Parkinson’s disease
A team of researchers has suggested that Parkinson’s disease may have an infectious or autoimmune origin. This study was carried out by NeuroGenetics Research Consortium, an international team of researchers led by Haydeh Payami, research scientist at the New York State Department of Health Wadsworth Center.
The clinical directors for the study were Dr. Cyrus Zabetian, associate professor of neurology at the University of Washington and VA Puget Sound Health Care System, Stewart Factor at Emory University, and John Nutt at Oregon Health and Sciences University.
From Esciencenews.com:
People who take non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen) have a reduced risk of developing Parkinson’s disease, which also supports an immune-related mechanism. The protective effect of NSAIDs is not the same for everyone, likely because of genetic differences, and NSAIDs can have side effects. Pursuing the connection between Parkinson’s disease and inflammation, especially in the context of variable genetic makeup, may lead to better, more selective drugs for treating Parkinson’s disease.
Consortium leaders recognize the study would not have been possible without the precious help from volunteer patients. “This type of research could not be done if it weren’t for the willing and dedicated individuals who volunteer as research subjects,” said Payami, who acknowledged that some study subjects participated for nearly two decades.
The study results are expected to help clinical practice in taking a fresh look at the possible role of infections, inflammation, and autoimmunity in Parkinson’s disease.
Tags: ibuprofen, NSAIDs, Parkinson's disease, steroidal
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