Archive for June, 2010

Cardiac conduction disease that necessitates pacemaker implantation in millions of patients worldwide can be triggered by genetic mutation. This finding was disclosed by studies that were started in an Amsterdam emergency room to offer the first molecular insight into a disorder.

According to report’s senior author, Dr. Jeffrey R. Balser, associate professor of Anesthesiology and Pharmacology and holder of the James Tayloe Gwathmey Physician-Scientist Chair at Vanderbilt University, there was little to no guidance on the molecular mechanisms that may possibly make a contribution to Acquired conduction disease, a disorder that affects people as they grow older.

From Sciencedaily.com:

“The heart is very sensitive to how its sodium channels work, and we suspect that aging may have subtle effects on sodium channels, not unlike the effects we see in this unusual family. We don’t know that yet, but at least we have some insight now into how sodium channel defects can produce isolated conduction disturbances.”

Balser and colleagues also made the surprising discovery that steroids inhibit the effect of the mutation. Steroids were used to treat the Dutch child before it was understood that she had a mutation-her physicians originally thought that inflammation of the heart might have been preventing normal conduction. Oddly, steroids improved her condition.

Likewise, when the investigators bathed the cultured mutant channels in steroids before studying their behavior, the functional defects disappeared.

“We theorize that steroids are inducing the production of a protein that interacts with the sodium channel and somehow cancels out the effects of the mutation,” Balser said. “We’d really like to know if there is such a protein and what it is-if we knew that, it might be possible to provide that protein, instead of pacemakers, to patients with acquired conduction disease.”

The studies were supported by the Interuniversity Cardiology Institute Netherlands, the Dutch Heart Foundation, and the National Institutes of Health and the list of collaborators on the Nature report included Vanderbilt scientists Hanno Tan and Prakash Viswanathan, and researchers in Amsterdam and Groningen, the Netherlands: Margreet Bink-Boelkens, Connie Bezzina, Gertie Beaufort-Krol, Peter van Tintelen, Maarten van den Berg, and Arthur Wilde.

If you are looking to buy testosterone suspension, we recommend you to have complete insights on this performance enhancing drug and testosterone derivative to avoid steroid abuse, knowingly or unknowingly. Read on!

Testosterone Suspension is a derivative of testosterone, which is the sex hormone in males. This testosterone derivative is available in oral and injectable forms and is primarily used to enhance the level of performance, on a continuing basis and without any fail. It is also effective in burning fat and in promoting the processes of nitrogen retention & protein synthesis, which means that the body will be in a better position than ever to build solid muscles after being administered with testosterone suspension.

This derivative of testosterone has no attached esters that mean that you get 100 mg of testosterone with 100 mg of testosterone suspension, which is quite unique to this anabolic steroid. This steroid is also useful in improving the count of red blood cells and endurance, which can be extremely useful to promote dramatic results during intense workouts.

The active life of testosterone suspension is 1-2 days and its anabolic/androgenic ratio is 100/100. Its recommended dose is 50-150 mg/day or 350-1000 mg/week for men. This drug can be taken with or without meals and is not recommended for use by women and girls. Testosterone suspension is often stacked with Dianabol and Anavar in order to get the most out of a steroid cycle.

We hope that this piece of information on testosterone suspension, an exceptional testosterone derivative and anabolic steroid, was useful in creating and maintaining awareness.

Members of the medical community have often testosterone for every bad thing in this world but the biggest of all raps came from the biomedical community that suggested a correlation between elevated testosterone levels and a suppressed immune system.

Stanton Braude, Ph.D., a lecturer in biology in Arts and Sciences and a biologist at the Washington University in St. Louis, suggested a completely turnaround for the hormone.

From Sciencedaily.com:

Braude came across a new body of research — about a dozen studies in all over the past five years — that questions the whole idea of immunosuppression and suggests that, instead of suppressing the immune system, testosterone and other steroids play a key role in what’s called immunoredistribution.

“The redistribution hypothesis predicts that when you are under stress the total number of immune cells in your body remains the same but are sent where they are most useful — to the skin to anticipate getting wounded and prevent infection,” Braude explains. “This makes perfect sense from an evolutionary standpoint. Now, today, with people constantly stressed, those immune cells aren’t protecting your gut from a virus or your lungs from an infection or a cold. So, you might get these illnesses, but the immune cells are out there protecting the skin. Personally, between gangrene and a cold, I’ll take the cold.”

Braude’s new idea is that testosterone signals infection-fighting white blood cells to go out of the blood stream and into the skin. He says it’s also possible that testosterone merely triggers the stress response, and other steroids from the adrenal gland then execute the redistribution.

“The bottom line is that a blood test of a highly parasitized breeding male peacock would show high testosterone but low white blood cell counts because the cells are temporarily out of the blood stream and in the skin,” Braude says.

The latest testosterone immunoredistribution hypothesis from Braude was published in an issue of Behavioral Ecology.

Prazosin, which is a drug prescribed for treating high blood pressure and prostate enlargement, could be used for protecting the brain from damage caused by post-traumatic stress disorder, depression, Alzheimer’s disease, and schizophrenia.

The drug, which is recommended as an antipsychotic medication, could inhibit the increase of steroid hormones, glucocorticoids.

From Sciencedaily.com:

Scientists believe stress activates a neurochemical response in the brain that triggers the release of glucocorticoids in the brain, and that high levels of glucocorticoids in blood serum are associated with such psychiatric conditions as schizophrenia, depression, PTSD and Alzheimer’s disease. This mechanism has been linked to decreases in cognitive performance in older people who are not suffering from clinical dementia.

“Our hypothesis is that just being afraid of being blown up all the time means you have high levels of steroids all the time,” Berger said, referring to PTSD among military personnel.

Low levels of glucocorticoids have anti-inflammatory effects in the brain, but high levels can trigger inflammatory mechanisms that damage nerve cells by activating an enzyme that causes oxidative stress. Even a single exposure to a high dose of glucocorticoids can be sufficient to damage nerve cells: A previous study showed synthetic glucocorticoid therapy to treat autoimmune disorders such as rheumatoid arthritis can induce mood disorders, including psychosis, and cognitive impairment known as “steroid dementia” in severe forms.

The finding was revealed by researchers at the Oregon Health & Science University and Portland Veterans Affairs Medical Center and the study was funded by the U.S. Department of Veterans Affairs.

If you are looking for an exemplary oral steroid for bodybuilding, Proviron fits the bill perfectly. Let us read about this anabolic steroid to find out its benefits.

In the world of professional sports such as bodybuilding, Proviron is one of the most admired of all oral steroids. Also known as Mesterolone, Proviron is used to treat sexual dysfunction and restore the level of natural testosterone, especially after the end of a steroid cycle. It is worth noting here that sexual dysfunction and testosterone production are two of the biggest concerns for steroid users and Proviron is second to none to take care of these complications.

In addition to all these benefits, Proviron is also effective to improve the sperm count after it has been affected by use of harsh and aromatizable steroids or due to a health disorder. Proviron is also effective to create a balance in cases of androgen deficiency, which is a common problem faced by individuals with growing age. It is also useful for reducing the level of estrogen and improving the level of androgens and is therefore an exceptional pre-contest drug to say the least. Proviron is also admired for treating health disorders such as irritability, sleep disturbances, libido, and depression.

The chemical name of Proviron is 1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one and it is classified as A. 21.7 Male sex hormones. The molecular weight of this compound at the base is 304.4716 g/mol and its androgenic/anabolic ratio is 30-40/100-150. The recommended dose of Proviron is 25-100 mg per day, with or without meals but antiestrogens such as Nolvadex may be necessary in case the level of estrogen formation exceeds the normal.

In wake of the recently released report by the American Medical Association’s (AMA) Council on Science and Public Health, Dr. Thomas T. Perls, an associate professor of medicine at Boston University School of Medicine condemned the promotion and distribution of growth hormones for non-medical purposes.

The criticism of growth hormones and appreciation of AMA for assessing risks and benefits of DHEA, growth hormone, testosterone, and estrogen was made by Dr. Perls editorial appearing in the Future Medicine journal Aging Health.

From Sciencedaily.com:

There have always been nostrums and potions peddled for eternal youth. Most recently these have been what some entrepreneurs call “bio-identical” or “all-natural” hormones. What they mean by these terms varies from substances made from vegetables — such as soy or yams, which some claim have estrogen-like effects to, more commonly, drugs that are exactly the same as hormones prescribed by endocrinologists for specific diseases. Dr. Perls remarked: “The terms bio-identical or all-natural, particularly in the case of the drugs prescribed by endocrinologists, misleadingly convey a sense of safety to the gullible customer. Arsenic is all-natural to, and it even has some medical uses, but it is anything but safe.”

“The AMA’s review of the risks and benefits of these hormones in the setting of anti-aging and athletic enhancement is very important given its inclusion of the consensus and position statements of the key professional medical societies as well as the federal agencies that guard public health.” states Dr. Perls in the editorial.

Dr. Perls denounced the marketing of hormones, especially growth hormone and anabolic steroids, for the purpose of anti-aging.

A big population of youth notice stress and mood swings during the stages of puberty. In the past, researchers were unable to identify the reasons behind anxiety associated with puberty.

But, recent findings have suggested that THP that is a hormone getting release in a response to stress could actually reverse the effects of puberty when the anxiety levels are on a high.

The findings appeared in an edition of the journal Nature Neuroscience.

From Sciencedaily.com:

Specifically, the GABA-A receptor is the target for steroids, such as THP (or allopregnanolone), which reduce anxiety. GABA-A receptors calm activity in the brain. As such, they are the targets for most sedative, tranquilizing drugs.

One sub-type, GABA-A receptors containing the delta subunit, such as alpha4-beta2-delta, has the highest sensitivity to steroids. In order to study its role in puberty, the researchers used a mouse model that reliably predicts the human condition. In this rodent model, the alpha4-beta2-delta receptor normally has very low expression, but increases dramatically at the onset of puberty in the part of the brain that regulates emotion. Paradoxically, THP reduced the inhibition produced by these alpha4-beta2-delta GABA-A receptors, increasing brain activity to produce a state of increased anxiety. Stress also increased anxiety at puberty, due to the paradoxical effects of this hormone that is released by stress.

Researchers led by Sheryl S. Smith, PhD, professor of physiology and pharmacology at SUNY Downstate Medical Center, reported these findings.

Bodybuilding is one professional sport that demands dedicated efforts complemented with a good diet, expert advice, and right knowledge about performance enhancing drugs. If you are looking for the most effective oral anabolic for bodybuilding rendezvous then Oxymetholone is the name you have been looking for.

Oxymetholone, also known as Anadrol, is an exceptional drug because of its undoubted effectiveness. This drug does not bind strongly to the androgen receptor and offers non-androgen receptor-mediated effects.

Chemical Properties

The chemical name of Oxymetholone is 17β-hydroxy-2-(hydroxymethylene)-17-methyl-5α-androstan-3-one and its inactive ingredients are starch, lactose, povidone, and magnesium stearate.

Benefits of Oxymetholone

Oxymetholone can bring in dramatic muscle gains in a short span of time. In addition to that, it is highly useful for relieving joint pain during exercise sessions. Oxymetholone is also considered useful for increasing the count of RBC (red blood cells) so that the body can get absorb more of oxygen to get benefited from improved performance levels.

Recommended Dose

The recommended dose of Oxymetholone for men is 25 mg/day, with or without meals. The recommended dosage of Oxymetholone for women is 12.5 mg/day, with or without meals.

Steroid Stacking

Oxymetholone can be stacked with Oxandrolone, Primobolan, or Trenbolone. Since the use of Oxymetholone does not lead to aromatization or conversion to estrogens, use of ancillary drugs or anti-estrogens is not required.

Storage

Oxymetholone is required to be kept at a controlled room temperature of 20° to 25°C (68° to 77°F) with excursions permitted to 15° to 30°C (59° to 86°F).

Expensive surgery and unnecessary secondary referral can be avoided by patients afflicted with otitis media with effusion (OME) through non-surgical treatment options.

The cost efficacy of topical intranasal steroids to treat otitis media with effusion (OME) in primary care from the perspective of the UK National Health Service was evaluated by a recent study.

From MedicalNewsToday.com:

Epidemiological studies of OME reveal that it affects 50-80% of children by the age of five. Without effective intervention, severe OME can cause significant hearing loss, which may result in linguistic, developmental, behavioural, motor and social impairment. Although many OME cases resolve spontaneously, referral rates from primary care remain high, with approximately 1-5 per 1000 children in the general population undergoing surgery (grommets) each year.

The study was led by Dr. Stavros Petrou from the University of Oxford.

Says Dr. Petrou: “This study demonstrates that the current use of topical steroids for OME is unlikely to represent an efficient use of scare public resources.”

This will be discussed in detail in Value in Health, the official journal of the International Society for Pharmacoeconomics and outcomes Research.

Value in Health (ISSN 1098-3015) publishes papers, concepts, and ideas that advance the field of pharmacoeconomics and outcomes research and help health care leaders to make decisions that are solidly evidence-based. The journal is published bi-monthly and has a regular readership of over 5,000 clinicians, decision-makers, and researchers worldwide.

The study, led by Dr. Stavros Petrou from the University of Oxford, demonstrated that topical steroids are unlikely to be a cost-effective option to treat OME in general practice.

The quest of attaining solid muscles and performance improvements is guiding professional sportsmen to anabolic steroids such as Tetrahydrogestrinone (THG).

Approximately 9 percent of bodybuilders paying a visit to gymnasiums in the United Kingdom were found to make use of steroids to improve the quality of muscles and performance, as per a study.

From MedicalNewsToday.com:

Made from the male hormone testosterone, they provide a chemical shortcut to strength and endurance. They promote the development of muscle, reduce fatigue and speed recovery after physical exertion by stimulating the production of protein. This makes them especially attractive to sprinters, weightlifters and throwers such as shot putters, for whom raw power is all-important.

The addition of four hydrogen atoms was all it took to make the anabolic steroid, gestrinone, undetectable by standard tests. A clever bit of work by chemists transformed it into tetrahydro-gestrinone (THG), providing some sportsmen, apparently, with the means to cheat.

The alarm was raised when a used syringe with a barely visible residue inside it was provided by an anonymous track and field coach to the US Anti-Doping Agency. From that residue, a University of California laboratory was able to identify the droplets as THG and then devise a test that would detect it in athletes‘ urine.

UK Sport said yesterday the test for THG would be introduced in Britain as soon as possible. About 7,500 random drug tests are done each year by sport’s governing body, of which 2 per cent are positive.

Stimulants such as ephedrine were found to be the second-most popular sports drugs for sportsmen after anabolic steroids.