Archive for February, 2010

Administration of steroids and a direct test for antibodies may hold the key for treating deafness caused by immune system attack.

This kind of deafness occurs when immune system of the body instead of offering protection against diseases goes haywire and causes havoc to the body systems. It is, usually, seen that the inner ear is the easiest prey during such an attack and this complication can be seen in thousands of people each year.

From News-Medical.Net:

Sometimes, with the help of steroids, some will get part or all of their hearing back, but many are left to cope with partial or total deafness without knowing the cause.

Why this happens is unexplainable.

However, new research at the University of Michigan’s Kresge Hearing Research Institute may help more patients find out quickly if steroids will help them, or if they can be spared the drugs’ harsh side effects.

The research may also extend the definition of the condition, known as autoimmune sensorineural hearing loss or AISNHL, and help more people get a firm diagnosis of what’s causing their mysterious hearing loss.

The researchers studied 63 people with rapidly progressing hearing loss in Michigan, Pennsylvania and Indiana, and 20 people with normal hearing.

Although the patients were suspected of having an auto-immune cause for their hearing loss, and all received steroids, a formal diagnosis had not been given.

Senior author Thomas Carey, Ph.D., a professor and distinguished research scientist at the U-M Medical School and department chair in the School of Dentistry, said that steroid treatment may offer insights for regaining the hearing ability via a direct test for antibodies.

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Patients with chronic obstructive pulmonary disease (COPD) and using inhaled corticosteroids face a reduced mortality risk, as per a new study published in the September issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians (ACCP).

The research revealed that patients who were administered with inhaled corticosteroids within a period of one month of hospital discharge noticed reductions of 25 and 38 percent in terms of all-cause mortality rate and cardiovascular-related deaths in patients using steroids paired with beta-agonists, respectively.

From News-Medical.Net:

Researchers also found a 23 percent reduced risk of death when comparing the effects of inhaled steroids with bronchodilators in patients in the 65+ group. In all cases, the most significant results were found when inhaled corticosteroids were administered within the first 30 days following hospital discharge.

“Our results indicate that the effect of inhaled corticosteroids is relatively short-term and that those currently using it are relatively better protected, ” said Dr. Macie. “Inhaled corticosteroids should be prescribed as soon as clinically indicated. By treating COPD with inhaled corticosteroids, we have the potential to reduce the effect and prolong life.”

“The findings from this study are intriguing for clinicians and point to the need for further research to define the role and mechanisms of the effect of inhaled corticosteroids on both cardiovascular and respiratory mortality,” said W. Michael Alberts, MD, FCCP, President of the ACCP.

Author Christine Macie, MD, FCCP, Cambridge Hospital, Ontario, Canada, said that the study evaluated the effects of corticosteroids and was endorsed by resulting highlighting that survival is longer in patients using inhaled corticosteroids.

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In the world of sports, anabolic steroids are trusted names. This is not because there is so much hype associated with them because they have helped sportsmen become icons and legends by delivering dramatic performances on a continuous basis. The fact that steroids improve the levels of stamina, performance, and muscle mass, and body strength without building fatigue is something unique to the use of steroids.

Not only this, steroids are also used by sportsmen to treat severe health complications such as Asthma and Alzheimer’s disease to name a few. The fact that steroids are now easily accessible and affordable is one of the other reasons why they have became a part of today’s sports community.

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The potential risk of an asthma attack relapse can be reduced to a significant extent by administering a short corticosteroid course after patients are discharged from the hospital, according to a Cochrane Systematic Review.

Carol Spooner, a colleague, said that this systematic review strongly endorses the use of systematic corticosteroids for treating outpatients after getting them discharged from the hospital on the event of an attack.

From News-Medical.Net:

This updated finding was drawn after reviewing data in six trials that together involved 374 people.

Between 12% and 16% of people who are discharged from hospital after having an asthma attack have a relapse within two weeks. “There is considerable debate about the best way of treating people who have asthma attacks, including the dose, method of delivery and timing of delivery of corticosteroids. Our research found clear evidence that people who arrived at a hospital with acute asthma and were well enough to be discharged benefited from the addition of corticosteroid therapy,” says lead author Professor Brian Rowe, who works at the University of Alberta, in Edmonton, Canada.

It was also noted that administration of steroids is also useful for reducing need of inhalers besides prolonging related benefits for a period of three weeks.

In the world of testosterone derivatives and anabolic steroids, Testosterone Enanthate is one name that commands immediate respect from one and all due to its unique benefits.

Testosterone enanthate is considered to be one of the obvious choices of every bodybuilder, celebrity, and sportsman on a bulking cycle. This is simply because this derivative of testosterone promotes instant and dramatic gains in the levels of muscle, water weight, and fat. This anabolic steroid is recommended to all those who are keen to create and maintain stable blood levels along side minimizing frequency of injections.

The chemical name of testosterone enanthate is 4-androstene-3-one,17beta-ol and its ester molecular weight is 130.1864 g/mol (enanthoic acid, 7 carbons). The long-lasting single ester steroid is more effective than the cypionate version of testosterone since it has more of steroid weight than testosterone cypionate.

Potential users of testosterone enanthate must arrange for ready supplies of anti-estrogens such as Clomid, Arimidex, or Nolvadex this steroid has a high aromatization rate and users can experience a high level of estrogen formation.

Testosterone enanthate can be stacked with steroids such as Anavar, Clenbuterol, Dianabol, Deca durabolin, Primobolan, Equipoise, or Winstrol for better results during a bulking cycle. The best way to use Testosterone enanthate is done at a dose of 500 mg week, with or without meals, for a maximum period of ten weeks at a stretch.

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According to two abstracts highlighting Emory research on the hormone were presented at the 2009 Society for Neuroscience (SFN) meeting in Chicago, Progesterone can be highly effective for treating patients suffering from traumatic brain injury and is therefore tested for optimization.

This trial was developed by Donald Stein, PhD, Asa G. Candler Professor of Emergency Medicine at Emory School of Medicine.

From Sciencedaily.com:

One of the SFN abstracts reports on progesterone analogues that are more water-soluble. This work comes from Stein and his colleagues in collaboration with the laboratory of Dennis Liotta, PhD, Emory professor of chemistry.

Currently, the lack of water solubility limits delivery of progesterone, in that the hormone must be prepared hours ahead and cannot be kept at room temperature. Small chemical modifications may allow similar compounds with the same effects as progesterone to be given to patients closer to the time of injury.

According to the results, two compounds similar to progesterone showed an equivalent ability to reduce brain swelling in an animal model of traumatic brain injury.

The second abstract describes evidence that adding vitamin D to progesterone enhances the hormone’s effectiveness when applied to neurons under stress in the laboratory. Like progesterone, vitamin D is a steroid hormone that is inexpensive, has good safety properties and acts on many different biochemical pathways.

It was noted by the authors that a small amount of Vitamin D may improve the ability of progesterone to guard neurons from excito-toxicity, biggest cause of brain injury and cell death.

If you are looking to exceed your own expectations on the field, it is time for you to make a right decision with testosterone cypionate. Read on!

In the world of high-quality anabolic steroids, testosterone cypionate is one name that is admired by one and all due to its never-ending list of unique advantages. This derivative of testosterone, the male sex hormone, is an anabolic steroid with a difference.

The cypionate version of testosterone is hailed by many bodybuilders and athletes as the most powerful of all forms of testosterone derivatives. Reason – very simple – this steroid promotes enhancements in the levels of stamina, performance consistency, and muscle gains like nothing else can.

Available in oral as well as injectable forms, testosterone cypionate is easy on the liver and can be stacked with almost every steroid such as dianabol, primobolan, equipoise, clenbuterol, and Deca-Durabolin for optimizing benefits and deliver dramatic results on a consistent basis.

The chemical structure of this testosterone derivative is 4-androstene-3-one,17beta-ol and its ester molecular weight is 132.1184 g/mol (cypionic acid, 8 carbons).

The recommended dose of testosterone cypionate is 20-100 mg per week, with or without meals. This long-lasting, single-ester steroid comes with a length of eight carbons and is generally stored in the adipose tissue when administered through an intramuscular injection. In cases where the users of testosterone cypionate experience a high level of estrogen formation, anti-estrogens such as Clomid, Arimidex, or Clomid can be used at end of the steroid cycle.

According to a finding appearing in the December issue of Archives of Ophthalmology, one of the JAMA/Archives journals, injecting the corticosteroid triamcinolone directly into the eye can considerably slow down the progression of diabetic retinopathy.

Diabetic retinopathy is a complication of diabetes that can result in loss of vision and blindness.

From Sciencedaily.com:

Corticosteroids have been shown to interfere with the creation of new blood vessels, possibly by reducing the production of compounds that spur their growth, the authors note. However, steroids are also associated with other eye diseases.

“Use of this intravitreal [injected into the eye] corticosteroid preparation to reduce the likelihood of progression of retinopathy is not warranted at this time because of the increased risk of glaucoma and cataract associated with intravitreal steroid use,” the authors write. “Any treatment to be used routinely to prevent proliferative diabetic retinopathy likely needs to be relatively safe because the condition already can be treated successfully and safely with panretinal photocoagulation. Nevertheless, further investigation with regard to the role of pharmacotherapy for reduction of the incidence of progression of retinopathy appears to be warranted.”

Neil M. Bressler, M.D., of Johns Hopkins University School of Medicine, Baltimore, and colleagues in the Diabetic Retinopathy Clinical Research Network conducted the study that involved 840 eyes of 693 participants having macular edema.

When it comes to improvements in terms of muscle mass and body strength, professional as well as budding sportsmen rely on Clenbuterol. Read on!

Clenbuterol, which is also known as Clen or Spiropent, is an anabolic steroid that can be best described as a powerful testosterone derivative. This selective Beta-2-symphatonimetric agonist is also known as Contraspasmina, Broncodil, and Clenbuteral.

It has the chemical formula of C12H18 CI2N2O and its chemical name is 4-Amino-alpha-[(tert-butylamino) methyl]-3,5-dichlorobenzyl alcohol Monohydrochloride. Having an approximate active life of 36-48 hours, Clenbuterol is an anabolic steroid with a difference. The anti-catabolic anabolic product does not promote retention of fluid and is therefore effective in promoting weight loss without any side effects or troubles. Apart from all these benefits, Clenbuterol is also effective when it comes to reducing the rate of protein in the muscle cells besides promoting rate of muscle cells.

It is best stacked with Cytomel. When used alone, the recommended dose of Clenbuterol is 10-25 mg per day. Available in oral as well as injectable form, this pre-contest drug improves the aerobic capabilities so that attaining a lean appearance is easy. It is highly important to note that low-grade Clenbuterol or counterfeit Clen or Clenbuterol abuse can result in side effects such as nausea, insomnia, headache, palpitation, limb tremor, tachycardia, excessive sweating, or anxiety. For optimum benefits, it is required to be kept at a controlled room temperature of 15-30°C.

In the world of medications, this anabolic steroid is used to treat medical complications such as asthmatic bronchitis, bronchial asthma, pulmonary emphysema, and acute and chronic spastic bronchitis.

All in all, Clenbuterol is one anabolic steroid that you can easily trust and for obvious reasons.