Archive for February, 2010

When a combination of steroid drugs and MS drug is administered to patients suffering from multiple sclerosis (MS), the level of disease activity can be reduced to a significant extent. This finding was revealed by a study presented as a part of the Late-breaking Science Program at the American Academy of Neurology’s 61st Annual Meeting in Seattle.

From Sciencedaily.com:

For the study, people with MS received the steroid drug methylprednisolone in monthly “pulses,” or three doses over three days, in addition to regular weekly treatment with the drug interferon beta-1a. The steroid drug has typically been used only to treat acute MS attacks, not as an ongoing treatment.

The study involved 341 people with relapsing-remitting MS. Half of the participants received both drugs; half received only the interferon drug plus a placebo. The participants were seen every three months during the three-year study for evaluation.

The participants had the disease for an average of three years and had not yet received a disease-modifying drug such as interferon.

Those who received both drugs had 38 percent fewer relapses, or times when the disease is active, than those receiving only the interferon drug. They also improved slightly on a test of MS disability, while the scores for the placebo group decreased slightly.

It was noted by study Mads Ravnborg, MD, of the Danish Multiple Sclerosis Research Center at Copenhagen University Hospital in Denmark that both drugs seem to benefit from a synergy when taken together with an aim to offer beneficial effect on the disease activity as against use of the MS drug in isolation.

In the world of bodybuilding where success of an anabolic steroid is judged purely on the merits of effectiveness, Tren Fina 75 is one name that commands immediate respect from all.

Tren Fina 75, which is also known as Tren Fina or Trenbolone or Tren, is admired for its unique characteristics. This exemplary anabolic is useful to promote delivery of dramatic performances without a sense of fatigue and coming closer to steroid side effects.

Moreover, it is an exceptional anabolic product for a bulking steroid cycle as well as a cutting steroid cycle. It helps users to gain or lose body weight in addition to muscle mass and body strength gains at the same time, which is something unique to it. Tren is one of those few steroids that does not aromatize or get converted to estrogen, which means that the risk of fluid retention or gynecomastia is eliminated even before they appear.

Tren Fina 75 has an approximate active life of 2-3 days and is available in oral and injectable forms.

Recommended Dose

The recommended dose of Tren Fina 75 is 75 mg per day for a maximum period of 6-8 weeks, with or without meals. After the last week, users should discontinue the usage for 8 weeks, and restart again so that the body does get immune to Tren’s action mechanism and can reap optimum benefits.

Tren Fina 75 can be stacked with other steroids such as Dianabol or Testosterone during a bulking steroid cycle and with Primobolan or Winstrol during a cutting steroid cycle.

Researchers from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health, and other institutions, have been able to identify a new autoinflammatory syndrome that affects children around the time of birth.

The syndrome is known as DIRA (deficiency of the interleukin-1 receptor antagonist).

From News-Medical.Net:

The scientists identified nine patients from six families with DIRA in the Canadian province of Newfoundland, the Netherlands, Lebanon, and Puerto Rico. Those who were alive at the time of diagnosis – six in all – were treated with anakinra, a drug that is normally used for rheumatoid arthritis and is a synthetic form of human IL-1Ra. Although the patients were resistant to other medications such as steroids, most responded successfully and immediately to anakinra. “Our first patient had been unresponsive to several treatments, and his health care team had almost given up. But with anakinra, he was out of the hospital in 10 days and his symptoms resolved,” Dr. Goldbach-Mansky said.

Although the mutation that causes DIRA is rare, as many as 2.5 percent of the population of northwest Puerto Rico are carriers. Since DIRA is recessively inherited, these data suggest that it may be present in about 1 in 6,300 births in this population. Because the mutation was found in three independent Dutch families, newborn screening for DIRA in this population, as well as that of northwest Puerto Rico, may be warranted, Dr. Goldbach-Mansky said.

Children affected by this syndrome show a wide variety of severe and potentially severe symptoms including bone tissue swelling.

If you have been suffering from breathing disorders or exercise-induced bronchospasm, Albuterol is one trusted name to provide significant relief.

Albuterol, placed under the category of bronchodilators, is a highly effective drug for offering relief to individuals suffering from exercise-induced bronchospasm and breathing disorders including asthma.

This drug has an appearance of white to off-white crystalline solid and is slightly soluble in ethanol and soluble in water. The chemical name of Albuterol is 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl) phenol; sulfuric acid.

Recommended Dose of Albuterol

The recommended dose of Albuterol is two puffs or inhalations after every 4-6 hours for adults and children over the age of 4 years. To treat asthma, the recommended dose is two puffs every 15-30 minutes before exercise sessions. If one dose is missed, it should not be taken along with the next dose.

When abused or of a low-grade quality, Albuterol use can lead to possible side effects such as dry mouth, dizziness, nervousness, tremor, and sweating.

Albuterol is required to be kept at a controlled room temperature of 25° C (77° F) with excursions permitted up to 15-30°C (59-86°F). It must be kept at a good distance away from children, unauthorized usage, heat, moisture, and sunlight. It is worth nothing that exposure to a temperature above 120°F may result in bursting of Albuterol. Moreover, Albuterol must be kept at a fair distance from the eyes during usage and should never be punctured or incinerated.

We hope that this information on Albuterol was useful to you in more than just a way.

A chemical used in inhalers such as salbutamol or salbuterol belonging to a leading brand may actually worsen the allergy, as per findings disclosed in a meeting of the American Academy of Allergy, Asthma and Immunology in San Francisco.

Fears were expressed about the possible reaction between the inhaler compound and steroids, which are used to prevent asthma attacks.

From News-Medical.Net:

Millions of asthma sufferers use the inhalers also known as salbutamol or salbuterol to provide relief from wheeziness, as well as inhaled steroids to prevent the condition occuring. But the chemical byproduct in Ventolin inhalers may weaken the steroids‘ anti-inflammatory effect.

The findings were revealed to a meeting of the American Academy of Allergy, Asthma and Immunology in San Francisco yesterday.

Dr Mark Aronica, of the Cleveland Clinic in Ohio, said: ‘The concern is that this chemical could build up in patients who take the drug frequently. ‘We need clinical studies to find out whether this is the case.’

This finding is expected to encourage clinical studies in the near term for eliminating the possible risk due to the presence of inhaler compound.

If you are looking for an exceptional health product then Oxandrolone is one name that would surely be of an interest to you.

Oxandrolone, which is also known as Anavar or Anvar, is one of those anabolic steroids that have the unique ability of interacting with the androgen receptors in target tissue for the purpose of facilitating weight gains. This is the reason why Oxandrolone is admired by bodybuilders and sportsmen looking to gain some extra kilos under the belt, especially those participating in weight categories.

The chemical name of Oxandrolone is 17ß-hydroxy-17a-methyl-2-oxa-5a-androstan-3-one and its inactive ingredients are magnesium stearate, hydroxypropyl methylcellulose, lactose, and cornstarch.

Recommended Dose

The recommended dose of Oxandrolone is 2.5-20.0 mg/day, with or without meals, and given in 2 to 4 divided doses. For male sportsmen, the recommended dose is 50-150 mg/day for a maximum of 42 days at a stretch and then absenteeism of 42 days so that the body does not get immune to the action mechanism or benefits of Oxandrolone. For women, the recommended dose is 20-90 mg/day.

Oxandrolone Abuse

The abuse of Oxandrolone can lead to severe health complications such as reduced glucose tolerance, changes in libido, edema, menstrual irregularities, and insomnia.

Tips and Precautions

Oxandrolone must be used only after a qualified medical advice and the use must be in accordance with the advice. Low-grade quality or abuse of Oxandrolone can lead to side effects. This drug is not meant for individuals having an existing allergy to oral anticoagulants.

According to a study presented at the annual meeting of the American Society for Bone and Mineral Research in Denver, a presently recommended osteoporosis drug can prove to be effective for preventing cartilage loss arising due to osteoarthritis after a joint injury.

Currently followed drugs such as steroids or non-steroidal anti-inflammatory agents (e.g. Advil, Aleve) may be useful for reducing pain but not effective for addressing loss of cartilage because of osteoarthritis, which is assumed to affect more than 50 million people by 2020 in the United States alone.

From News-Medical.Net:

Parathyroid hormone (PTH), known as teriparatide in drug form, has emerged as a major player in the maintenance and healing of bone, and the race is on to design new applications for it. Past studies have established that PTH prevents chondrocytes from undergoing maturation, and stimulates their proliferation, preserving larger pools of cartilage cells in the joint. Signaling molecules like PTH have their effect in the body by interacting with specifically shaped proteins on the cell surfaces called receptors. PTH docks into its receptors, like a ship coming into port, which changes the shape of the dock such that biochemical signals are sent.

The authors of the current study observed that chondrocytes within injured and degenerating cartilage have more PTH type 1 receptors on their surfaces. This makes them especially sensitive to the PTH signal that prevents harmful chondrocyte maturation into bone in the joint cartilage. Thus, PTH therapy should increase the cartilage supply exactly where cartilage loss is causing disease.

Randy Rosier, M.D., Ph.D., professor within the Department of Orthopedics and Rehabilitation at the University ofRochester Medical Center , said that physicians are left with no answer when it comes to restoration of the cartilage in patients suffering from osteoarthritis.

In the world of bodybuilding, Hexarelin is one drug that is admired by all as it redefines anabolic and growth promoting effects without resulting in any side effect.

Hexarelin is one of the most trusted drugs when it comes to ensuring enhancements in terms of body weight and muscle mass. It is a synthesized small growth hormone releasing peptide (GHRP) known to facilitate secretion of IGF-1 (insulin-like growth factor-I) leading to improvement of the linear growth velocity.

The chemical name of Hexarelin is L-Histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide; {HIS}{D-2-ME-TRP}{ALA}{TRP}{d-PHE}{LYS}-NH2 and it is available in oral as well as injectable forms.

Hexarelin is often used as a performance enhancing drug in the worlds of sports and bodybuilding as easily enhances secretion of natural growth hormone besides healing joints. It is also considered useful for restoration of natural GH and IGF levels after a steroid cycle. The drug is also effective for improving the levels of serum phosphate and alkaline phosphate to a significant extent. Not only this, Hexarelin is also useful for improving the levels of muscle mass and new muscle fibers.

The recommended dose of Hexarelin is 200 mcg per day with or without meals. It is best stored at a controlled room temperature of 20° to 25°C (68° to 77°F). This drug must be kept at a good distance away from unauthorized use, children, heat, pets, and moisture.

In short, Hexarelin is one drug that you can easily trust when it comes to building solid muscle mass and redefining bodybuilding.

Prazosin, a drug for treating prostate enlargement and high blood pressure, may be an effective option to protect the brain from possible damage resulting from post-traumatic stress disorder, Alzheimer’s disease, depression and schizophrenia.

It was remarked by study co-author S. Paul Berger, M.D., assistant professor of psychiatry and behavioral neuroscience, OHSU School of Medicine and the PVAMC, that prazosin can prove its worth by protecting the brain from any damage due to excessive levels of corticosteroid stress hormones.

From News-Medical.Net:

“Our hypothesis is that just being afraid of being blown up all the time means you have high levels of steroids all the time,” Berger said, referring to PTSD among military personnel.

Low levels of glucocorticoids have anti-inflammatory effects in the brain, but high levels can trigger inflammatory mechanisms that damage nerve cells by activating an enzyme that causes oxidative stress. Even a single exposure to a high dose of glucocorticoids can be sufficient to damage nerve cells: A previous study showed synthetic glucocorticoid therapy to treat autoimmune disorders such as rheumatoid arthritis can induce mood disorders, including psychosis, and cognitive impairment known as “steroid dementia” in severe forms.

To determine the effects of prazosin, OHSU and PVAMC researchers, led by Altaf Darvesh, Ph.D., formerly of the OHSU Department of Psychiatry, administered a glucocorticoid called dexamethasone to rats, then measured the expression of a protein known as heat shock protein 70, or HSP70, that serves as a marker for neurotoxicity. Pretreatment with prazosin, an alpha-1 receptor antagonist, resulted in “significant” slowing of dexamethasone-induced expression in the cerebral cortex.

Berger further remarked that future research will be examining how steroids pose a threat to the brain and when prazosin should be administered to most effectively protect the brain against damage.x

When it comes to developing lean muscle appearance or solid muscle mass, there cannot be anything better and more reliable than Clenbuterol.

In the world of performance enhancing drugs, Clenbuterol is one name that is admired by every sportsman. This selective Beta-2-symphatonimetric agonist is an effective drug when it comes to losing body weight without any side effect.

Clenbuterol is known by many names in the world of sports such as Clen, Contraspasmina, Broncodil, Clenbuteral, and Spiropent. This pre-contest drug provides thermogenic effects in addition to mild anabolic properties, which are unique to it. It is available in many forms such as syrups, tablets, and injections.

Moreover, Clen does not facilitate fluid retention. This means that users on Clen can stay free from possible side effects of fluid retention without any troubles.

The chemical name of Clenbuterol is 4-Amino-alpha-[(tert-butylamino) methyl]-3,5-dichlorobenzyl alcohol Monohydrochloride and its molecular weight at base is 277.193 g/mol.

Having an approximate active half life of 35-40 hours, Clenbuterol facilitates reductions in protein rate in the muscle cells.

In the world of medicines, Clenbuterol is used to treat asthmatic bronchitis, bronchial asthma, pulmonary emphysema, and chronic spastic bronchitis.

Recommended Dose of Clenbuterol

For men following a 3-week cycle, the recommended dose of Clenbuterol is as follows:

Day 1-3 and Day 20-21 – 40 mcg/day

Day 4-6 and Day 18-19- 60 mcg/day

Day 7-8 and Day 16-17- 80 mcg/day

Day 9-11 and Day 14-15- 100 mcg/day

Day 12-13 – 120 mcg/day

This should be followed by a 3-week off period.

For women following a 3-week cycle, the recommended dose of Clenbuterol is as follows:

Day 1-4 and Day 19-21 – 40 mcg/day

Day 5-8 and Day 15-18- 60 mcg/day

Day 9-14 – 80 mcg/day

This should be followed by a 3-week off period.

Tips and Precautions

Clenbuterol should not be used by pregnant or expecting women due to its tocolytic action. It is required to be kept at a controlled room temperature of 15-30° C.