Archive for January, 2010

Whether it is the adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer or increasing the level of testosterone in the human body, Arimidex is one name that is trusted by all.

Arimidex, which is also known as Liquidex, is a wonder drug that is used for varying purposes. In the medical world, it is used as part of the adjuvant treatment of postmenopausal women with hormone receptor-positive early breast carcinoma (cancer). In the world of bodybuilding, it is used to increase the level of testosterone, the male sex hormone, in the human body to promote a sense of well-being and confidence.

This miracle drug is highly effective when it comes to inhibition of negative feedback loop that makes signal to the body for stopping the natural production of testosterone.

Arimidex, which is available in oral form, includes 1 mg of Anastrozole, a non-steroidal aromatase inhibitor. The chemical name is 1,3-Benzenediacetonitrile, a, a, a’, a’-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl) and its molecular formula is C17H19N5.

Recommended Dose

The recommended dose of Arimidex is one tablet of 1 mg per day, with or without meals.

It is important to note that only high-grade, quality Arimidex must be used and that too after and as per a qualified medical advice. Any contravention to medical advice can lead to side effects such as bone pain, peripheral edema, dyspnea, hot flashes, arthritis, insomnia, depression, nausea, and vomiting.

We hope that this information on Arimidex (Liquidex) was helpful to you in many ways.

If you are moving ahead in the quest of success and looking for the best anabolic steroid, Sustanon 250 is the name you need to look out for. Read on!

In the world of health and fitness, Sustanon 250 is one name that is way ahead of all. The reason is simple – it is described by scientists and users as the best anabolic steroid ever known to the mankind.

Let us read about Sustanon 250, the miracle drug, to gain a complete and clear insight.

Sustanon 250 can be best described as a powerful anabolic steroid that has been helping bodybuilders and sportsmen, all over the world, to realize their dreams. It does not bring any side effect unless abused or of a low-grade quality and this is what separates it from the rest in the world of steroids.

Sustanon has the chemical name of 17ß-hydroxyandrost-4-en-3-one and is available in oral as well as injectable forms. Having an approximate detection time of three months and active life of around three weeks, Sustanon is a mixture of four compounds of testosterone: testosterone propionate (30 mg), testosterone phenylpropionate (60 mg), testosterone isocaproate (60 mg), and testosterone decanoate (100 mg). All these compounds are released on a gradual basis so that the human body can easily reap optimum benefits.

Recommended Dose

The recommended dose of Sustanon 250 is 250 mg every week, and a maximum of 2000 mg or more per week. For sportsmen including bodybuilders, the recommended dose is 250-1000 mg per week. It is important to note that this anabolic steroid is not meant for consumption of female users, unless otherwise recommended by a qualified medical advice.

If you have been left shattered with the news of infertility or want to reap optimum benefits of anabolic steroids without excessive formation of estrogens, Letrozole is an amicable option for you. Read on!

In the world of quality drugs, Letrozole is one drug that has been trusted by one and all. Also known as Femara, Letrozole is recommended by doctors all over the world to patients suffering from infertility for ovulation induction. It is also clinically recommended for inhibiting the spread of breast cancer after treatment options such as Tamoxifen therapy have failed to live up to the expectations.

In the world of sports, Letrozole is used by bodybuilders and sportsmen to block or reduce estrogen formation at the end of a steroid cycle. The fact that it can minimize estrogen formation by as much as 98 percent is something unique to this anti-estrogen only. In addition to that, the risks of acne, gynecomastia, and water retention that are commonly associated with estrogens are reduced by this drug to a significant extent. Letrozole is highly effective for steroid users on bulking or cutting cycles that comprise of harsh androgens.

Apart from all these benefits, Letrozole is also effective in improving the levels of LH (Luteinizing hormone), FSH (Follicle-stimulating hormone), and SHBG (Sex hormone-binding globulin).

Chemical Structure

Femara is chemically described as 4,4′-(1H-1,2,4Triazol-1-ylmethylene)dibenzonitrile and has the molecular weight of 285.31 g/mol. Inactive ingredients of Femara are magnesium stearate, maize starch, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, talc, colloidal silicon dioxide, ferric oxide, hydroxypropyl methylcellulose, lactose monohydrate, and titanium dioxide.

Tips and Precautions

It is important to note that Letrozole must not be consumed when an individual is about to get engaged into activities such as driving or using a machine as it can result in fatigue or dizziness. In addition to that, Letrozole needs to be kept at a controlled temperature of 25°C (77°F) with excursions permitted up to 15-30°C (59-86°F).

Recommended Dose

The recommended dose of Letrozole is one tablet of 2.5 mg per day, with or without meals.

Testosterone, the male sex mone, is well known for stimulating human performance to a significant extent. This fact was reaffirmed by researchers at the University of Cambridge who found out that high morning testosterone levels can considerably influence performance of traders to help them make more than just average profits.

The involved scientists hypothesized that testosterone has the unique ability of influencing confidence and risk appetite that augment performance of traders.

From News-Medical.Net:

The influence of steroids naturally produced in the body (specifically testosterone and cortisol) may also provide insight into why people caught up in bubbles and crashes often find it difficult to make rational choices, unintentionally exacerbating financial crises.

Testosterone is a steroid hormone which controls competitive encounters as well as sexual behaviour. Testosterone in male athletes, for example, will rise prior to a competition and rise even further in a winning athlete (but decrease in a losing one). This increase of testosterone in the winner can increase confidence and risk taking and improve chances of winning yet again, leading to a positive-feedback loop termed the ‘winner effect’. However, too much testosterone can have a detrimental affect on the ability to assess risk rationally.

In order to determine how hormone levels affect those working in the financial sector, the researchers followed 17 City of London male traders for eight consecutive business days. To measure the traders’ hormones, they took saliva samples twice per day at 11:00 a.m. and 4:00 p.m., times that fell before and after the bulk of the day’s trading. At each sampling time, traders recorded their profit and loss (P&L).

Dr. John Coates, lead author, said that increased testosterone and cortisol levels can allow city traders to take more risks than traders with low testosterone and cortisol levels.

If you are looking for the most effective androgenic steroid in the world of anabolic steroids, you are surely searching for Anadrol. Read on!

Anadrol, which is also known as Oxymetholone, can be easily classified as a powerful anabolic steroid that is trusted by one and all. This steroid had helped and been helping thousands of bodybuilders and athletes to earn name, fame, and money in a short span of time. Offering instant and consistent results, Anadrol is an oral androgenic steroid that promotes the formation of red blood cells in the human body making it one of the treatment options for complications such as anemias. The steroid is also considered to be highly effective in preventing AIDS wasting.

The molecular weight of Anadrol is 332.482 g/mol at base and its chemical structure is 17 beta-hydroxy-2-hydroxymethylene-17alpha-methyl-5 alpha-androstan-3-one

This 17-AA steroid is pleasant in taste and is best used in oral form though it may be available in an injectable form. This anabolic steroid provides low to moderate androgenic effect in combination with strong anabolic effects. One of the greatest advantages of this steroid product is that it does not result in any side effect unless it is of a low-grade quality or abused.

Recommended Dose

The recommended dose of Anadrol is 50-100 mg per day taken as a single dosage, with or without meals. The use of anti-estrogens such as Clomid or Nolvadex may be required at the end of a steroid cycle in case the formation of estrogens exceeds after using this 17-alpha-akylated steroid.

In simple words, Anadrol is an effective oral androgenic steroid with varying benefits and no side effects.

arathyroid hormone (PTH), which is known as teriparatide in drug form, can prove to be an effective option for inhibiting cartilage loss due to osteoarthritis following joint injury. The hormone was also found to be effective for regenerating a part of cartilage lost due to osteoarthritis.

This finding was revealed by an early study presented September 12 at the annual meeting of the American Society for Bone and Mineral Research in Denver.

The presently recommended drugs such as steroids or non-steroidal anti-inflammatory agents (e.g. Advil, Aleve) may address pain but fail to address loss of cartilage because of osteoarthritis, which is believed to affect more than 50 million Americans by 2020.

From Sciencedaily.com:

“Right now physicians have no way to bring back cartilage in patients who have lost it to osteoarthritis,” said Randy Rosier, M.D., Ph.D., professor within the Department of Orthopaedics and Rehabilitation at the University of Rochester Medical Center. “Our current results, at least in mice, show that we can inhibit cartilage degeneration and improve the volume of cartilage in diseased joints. It’s remarkable enough that this compound delays the loss of cartilage, but these results show it also may be able to restore, at least to some extent, cartilage in already degraded joint surfaces.”

Researchers examined the impact of a daily dose of Forteo®/teriparatide, manufactured by Eli Lilly, and a generic version of teriparatide made by Sigma on the progress of OA following injury in study mice.

Experiments established a five-fold increase in PTH type 1 receptor expression in the articular cartilage of mice with injury-related osteoarthritis when compared to healthy cartilage. Injury triggers genetic mechanisms in an attempt to begin repairs, a repair response that may be responsible for the increase in PTH receptor in the joint. This in turn makes damaged cartilage particularly responsive to PTH.

This study was co-led by Erik Sampson, Todd O’Brien, Di Chen, Susan Bukata, J. Edward Puzas, Regis O’Keefe and Michael Zuscik within the Department of Orthopaedics and by Hani Awad in the Department of Biomedical Engineering at the University of Rochester Medical Center, and funded by the National Institutes of Health.

The use of anabolic steroids has always been a debated issue. While anti-doping officials are finding new ways to prevent steroid use, diuretics such as Aldactone are exceptional products for concealing the success secret.

Aldactone, which is also known as Spironolactone, is a diuretic that helps in hiding or masking the presence of anabolic steroids in the human body. It is used by bodybuilders, strength athletes, and other sportsmen to deliver dramatic on-field performances and yet remaining safe from doping tests.

The chemical structure of Aldactone is 17-hydroxy-7alpha-mercapto-3-oxo-17alpha- pregn-4-ene-21-carboxylic acid gamma-lactone acetate. It has the molecular weight of 416.5744 g/mol at base.

Action Mechanism

Aldactone helps in keeping a close check on the production of aldosterone besides having a minimizing effect on fluid retention. This means that it promotes enhanced muscle definition besides allowing its users to get a lean, muscular appearance.

In addition to that, Aldactone inhibits androgenic side effects from occurrence after the end of a steroid cycle. In sporting events such as boxing where weight classes are considered important, Aldactone is highly useful as it allows the users to compete in a weight category without compromising on muscle tissue in order to lose fat and body weight.

Recommended Dose

The recommended dose of Aldactone is 75-150 mg per day, with or without meals. For optimizing results, it can be taken alongside anti-estrogens such as Nolvadex or Clomid.

We hope that this piece of information on Aldactone, the diuretic, was helpful to you in more than just a way.

In the world of anabolic steroids, there is a very thin line between steroid use and steroid abuse. Let us read about abuse of steroids to gain a clear and complete understanding of the same.

When steroids are used for legal purposes such as treatment of medical complications and recommended by a qualified medical practitioner, the use is termed as ’steroid use’. On the other hand, steroid abuse is indiscriminate and unlawful use of steroids without a qualified medical advice. While steroid use provides benefits such as health complication treatment, abuse of steroids leads to severe health complications.

Steroids are abused by bodybuilders, athletes, body guards, construction workers, law enforcement officers, celebrities, and fitness-conscious people for gaining a competitive advantage. There is nothing wrong or illegal in using steroids but only if they are used under a medical advice.

Let us read about some side effects of steroid abuse to understand the concept in a clear manner.

Steroid abuse can lead to side effects such as hair loss, liver problems, insomnia, acne, headaches, jaundice, hypertension, aggression and hostility, irritability, anxiety, paranoia, mood swings, depression, suicidal thoughts, osteoporosis, menstrual irregularities, enlarged clitoris, and prostate and fertility problems. Apart from these health complications, steroid abuse can also lead to cancer, jaundice, liver damage, bleeding, hepatitis, gynecomastia, deepened voice, insomnia, and stunted growth.

After reading about the associated complications, one can easily understand that steroid abuse must be avoided at all stages. All in all, every one must stay away from indiscriminate usage of steroids so that steroid side effects do not happen at the first place.

A drug previously approved for curing non-Hodgkin’s B cell lymphoma and rheumatoid arthritis may prove its worth when it comes to treating severe ANCA-associated vasculitis.

The drug, Rituxan, can be as effective as cyclophosphamide, the current standard therapy. This finding was presented October 18, 2009 at the annual meeting of the American College of Rheumatology in Philadelphia.

From Sciencedaily.com:

In the current study, nine centers enrolled a total of 197 patients with severe Wegener’s granulomatosis or microscopic polyangiitis, two of the more common types of ANCA-associated vasculitis. Patients were given steroids and randomized to receive either the standard treatment with cyclophosphamide or Rituxan given at a dose of 375 mg/m2 weekly for four weeks. Investigators used the standard tools to assess disease status and remission. The study was rigorously designed and was double-blinded, meaning that neither patient nor doctor knew which drug individuals were getting.

At the time of the data analysis, 84 of the 99 (85%) patients in the Rituxan arm and 81 of the 98 patients (83%) in the cyclophosphamide arm had completed six months of follow-up. Investigators found that the treatments were equally effective in putting patients into remission and that, in fact, the treatment outcomes looked slightly better in patients receiving Rituxan (64% vs. 55%). This difference, however, was not considered statistically significant (P=0.21).

The Phase III trial was spearhead by Ulrich Specks, M.D., a professor of medicine in the Department of Pulmonary and Critical Care Medicine at the Mayo Clinic, and John Stone, M.D., MPH, director, Clinical Rheumatology, Massachusetts General Hospital and Hospital for Special Surgery was one of nine centers involved in the trial.

Robert Spiera, M.D., an associate attending rheumatologist at Hospital for Special Surgery in New York, said that Rituxan is as effective as cyclophosphamide in terms of remission. It was also said that patients treated with the drug do not experience infertility or secondary cancers, which have been concerns with the use of cyclophosphamide.

According to new findings from researchers at the Cedars-Sinai Medical Center, treatment of multiple myeloma involving steroid pills is an effective option offering significant relief to the affected patients.

Multiple myeloma is a type of cancer that is expected to affect more than 14,000 lives in the United States alone.

It was suggested by James Berenson, M.D., lead author of the Southwest Oncology Group sponsored study and Director of the Multiple and Bone Metastasis Program at Cedars-Sinai Medical Center, that the use of prednisone in response to an upfront chemotherapy may be considered as an effective treatment option for prolonging the lives of patients suffering from Multiple Myeloma.

From News.Bio-Medicine.Org:

Multiple myeloma occurs when the body makes an abnormally high number of cancerous plasma cells. When healthy, plasma cells help to protect the body from infection and disease by forming antibodies that attack foreign substances. But when the body makes too many plasma cells that all make the same type of antibody, this leads to multiple myeloma, causing damage to bones, severe bone pain, an overabundance of calcium in the blood, anemia, and a weakening of the immune system. Today, most patients with multiple myeloma receive initial treatment with chemotherapy or with high-dose chemotherapy followed by a stem cell transplant and many respond to treatment and achieve remission. However, all patients ultimately relapse with incurable disease, leading physicians to search for ways to prolong remission for as long as possible by using some type of maintenance therapy.

It was remarked by the researchers that patients can expect to easily maintain their remission and live for long than those not on prednisone after getting administered with oral prednisone in the long-term after chemotherapy treatment.